Can transthoracic echocardiography predict fluid responsiveness in shock after a mini-fluid challenge?

Not Applicable

Completed

• Conditions: Hypovolemic or septic shock; Signs and Symptoms; Hypovolaemic shock, septic shock

• Registration Number: ISRCTN10524328
• Lead Sponsor: Affiliated Provincial Hospital of Anhui Medical University (China)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-12-12
• Last Update Posted: 21 August 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

1. Evidence of inadequate tissue perfusion with acute circulatory failure defined as a systolic arterial pressure of 90 mmHg (or a decrease of 40 mmHg in a patient with hypertension)
2. Urine output below 0.5 ml/kg/h for over 1 h
3. Tachycardia (heart rate < 100/min)
4. Mottled skin
5. Clinical diseases of hypovolemic or septic shock associated with a systemic inflammatory response syndrome
6. Septic shock
7. Controlled massive hemorrhage
8. The attending physician clinically determined the need for volume expansion (VE)

Exclusion Criteria

1. Age < 18 years
2. Moribund
3. Cardiomyopathy
4. Pulmonary edema
5. Increased intracranial pressure
6. Pregnancy
7. Active bleeding
8. Atrial fibrillation
9. Cardiac arrhythmias
10. Myocardial ischemia or infarction within 1 month before the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Cardiac output (CO)<br>2. Stroke volume (SV)<br>3. Aortic velocity time index (VTI)<br>4. Left ventricular ejection fraction (LVEF)

Secondary Outcome Measures

Name	Time	Method
Area under the receiver operating characteristic curves (AUC) compared CO variations after 50 ml over 10 s (?CO50) and 500 ml over 15 min (?CO500) and the variation of VTI after infusion of 50 ml fluid over 10 s (?VTI50)