Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
试验速览
- 阶段
- 不适用
- 入组人数
- 146
- 试验地点
- 2
- 主要终点
- Dry eye
研究概览
简要总结
Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain characteristics which might predict those patients who will experience serious dry eye symptoms and complications after refractive surgery.
Research Design: This study is a twelve-month prospective non-randomized investigation.
Methodology: In conjunction with psychometric questionnaires and various measures of tear film quality (e.g. Schirmer's test, tear break up time, etc), impression cytology will be used to assess the intracellular signaling pathways of conjunctival goblet cells and to determine if alterations in this pathway exist. Alterations in this pathway would result in a reduced response by the mucin secreting conjunctival goblet cells thereby promoting the development of dry eye after refractive surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects will be recruited from those active duty soldiers that have requested refractive surgery. Subjects must be eligible for medical care at WRAMC.
- •Male or female, of any race, and at least 21 years old and not older than 40 years old at the time of the pre-operative examination, and have signed an informed consent. The lower age limit of 21 years is intended to ensure documentation of refractive stability and is the minimal age required by the FDA for informed consent for LASIK surgery.
- •Manifest refractive spherical equivalent (MSE) of up to 10.00 diopters at the spectacle plane with refractive cylinder up to 3.00 D.
- •Best spectacle corrected visual acuity of 20/20 or better in both eyes.
- •Patients who are willing to fill out dry eye questionnaires.
- •Demonstrated refractive stability, confirmed by clinical records. Neither the spherical nor the cylindrical portion of the refraction may have changed more than 0.50D during the 12- month period immediately preceding the baseline examination, as confirmed by clinical records.
- •All patients must be willing to return to the WRAMC Center for Refractive Surgery for follow up visits on Day1, Day 3, Day 7, and 1, 3, 6, and 12 months after their surgery.
- •Located in the greater Washington DC area for a 14-month period.
- •Consent of the subject's command (active duty) to participate in the study.
- •Access to transportation to meet follow-up requirements.
排除标准
- •Previous surgery or trauma to the study eye.
- •Dry eye as reflected by Schirmer's test with anesthesia of 0, subjective complaints or symptoms of dry eye, findings during the slit lamp exam that would be consistent with dry eye (e.g. superficial punctuate keratitis).
- •Female subjects who are pregnant, breast-feeding or intend to become pregnant during the study. This is a standard of care exclusion for refractive surgery at the Walter Reed Refractive Surgery Center because of the medications that are routinely given as part of the procedures. Standard of care analgesia consists of medications (e.g. narcotics) labeled as Pregnancy Category "C" by the FDA. Teratogenic effects are not known, however, physical dependence in the neonate may occur if the mother is given narcotics. Female subjects will be given a urine pregnancy test prior to participating in the study to rule out pregnancy.
- •Concurrent topical or systemic medications that may impair healing, including corticosteroids, antimetabolites, isotretinoin (Accutane), amiodarone hydrochloride (Cordarone) and/or sumatriptan (Imitrex).
- •Medical condition(s), which, in the judgment of the investigator, may impair healing, including but not limited to: collagen vascular disease, autoimmune disease, immunodeficiency diseases, and ocular herpes zoster or simplex.
- •Active ophthalmic disease, neovascularization of the cornea within 1mm of the intended ablation zone, or clinically significant lens opacity.
- •Evidence of glaucoma or an intraocular pressure greater than 22 mm Hg at baseline.
- •Evidence of keratoconus, corneal irregularity, or abnormal videokeratography in either eye.
- •History of recurrent erosions or epithelial basement dystrophy.
- •Patients with known sensitivity or inappropriate responsiveness to any of the medications used in the post-operative course.
- •Any physical or mental impairment that would preclude participation in any of the examinations.
结局指标
主要结局
Dry eye
时间窗: one year after surgery
次要结局
未报告次要终点
研究者
Samanta B. Rodgers
Assistant Director, Warfighter Refractive Eye Surgery Program and Research Center at FT Belvoir
Fort Belvoir Community Hospital