ong-term (3 years) ophthalmic safety and cardiac efficacy and safety of ivabradine administered orally at the therapeutic doses (2.5/5/7.5 mg twice daily [b.i.d.]) on top of anti-anginal background therapy, to patients with chronic stable angina pectoris

Not Applicable

Completed

• Conditions: Chronic stable angina pectoris; Circulatory System; Angina pectoris

• Registration Number: ISRCTN99185656
• Lead Sponsor: Institut de Recherches Internationales Servier (France)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-02-13
• Study Completion: 2015-09-30
• Last Update Posted: 4 May 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 97

Inclusion Criteria

1. Male or female patients (oral contraception if childbearing potential), aged greater than 18 years or having reached majority if the legal age of majority is above 18 years age and of any ethnic origin
2. Patients in sinus rhythm; resting heart rate greater than 60 beats per minute, with a history of chronic stable angina greater than 3 months before selection, no angina at rest and with a clinically stable angina greater than 3 months, at least 1 angina attack per month during the previous 3 months before selection
3. Patients who accept to undergo repeated visual tests and with a visual acuity greater than 0.5

Exclusion Criteria

1. Contra-indication to the administration of ivabradine
2. Patients with marked ocular conditions (significant altered vision and/or any evolutive underlying disease) known to have an impact on the ocular tests planned in the protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified