Phase I Trial of Bortezomib (NSC 681239, IND#58443) and Carboplatin in Recurrent or Progressive Epithelial Ovarian Cancer or Primary Peritoneal Cancer
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 试验地点
- 1
研究概览
简要总结
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth. Drugs used in chemotherapy such as carboplatin use different ways to stop tumor cells from dividing so they stop growing or die. Bortezomib may help carboplatin kill more tumor cells by making tumor cells more sensitive to the drug.
PURPOSE: Phase I trial to study the effectiveness of combining bortezomib with carboplatin in treating patients who have recurrent or progressive ovarian epithelial, primary peritoneal, or fallopian tube cancer.
详细描述
OBJECTIVES:
- Determine the maximum tolerated dose of bortezomib in combination with carboplatin in patients with recurrent or progressive ovarian epithelial, primary peritoneal, or fallopian tube cancer.
- Determine the toxicity of this regimen in these patients.
- Determine the pharmacodynamics of this regimen in these patients by measurement of 20S proteasome inhibition in whole blood.
- Correlate toxicity with 20S proteasome inhibition in a whole blood assay in patients treated with this regimen.
OUTLINE: This is a dose-escalation study of bortezomib.
Patients receive carboplatin IV over 30 minutes on days 1 and 8 followed by 1 week of rest during the first course of treatment. Beginning with the second course, patients receive bortezomib IV on days 1, 4, 8, and 11 and carboplatin IV over 30 minutes on days 1 and 8. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of bortezomib until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Once the MTD is determined, 8 additional patients are accrued and treated at that dose.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Histologically confirmed ovarian epithelial, primary peritoneal, or fallopian tube cancer
- •Recurrent or progressive disease
- •Received at least 1 prior platinum-based chemotherapy regimen containing carboplatin, cisplatin, or another organoplatinum compound for primary disease
- •May include high-dose therapy, consolidation, or extended therapy after surgical or non-surgical assessment
- •No brain metastases or leptomeningeal involvement
- •PATIENT CHARACTERISTICS:
- •Not specified
- •Performance status:
- •Karnofsky 70-100%
- •Life expectancy:
- •Not specified
- •Hematopoietic:
- •Absolute neutrophil count at least 1,000/mm^3
- •Platelet count at least 100,000/mm^3
- •Hemoglobin at least 8.0 g/dL
- •AST and ALT no greater than 2.5 times upper limit of normal
- •Bilirubin no greater than 1.8 mg/dL
- •Creatinine no greater than 1.5 mg/dL
- •Cardiovascular:
- •LVEF greater than 50% by radionuclide ventriculogram or two-dimensional echocardiogram
- •No peripheral vascular disease requiring surgical management
- •No prior myocardial infarction
- •No congestive heart failure
- •No orthostatic hypotension
- •No acute ischemia or significant conduction abnormality (bifascicular block, defined as left anterior hemiblock with right bundle branch block, second or third degree AV blocks) as evidenced by electrocardiogram
- •No prior cerebrovascular event
- •No peripheral neuropathy grade 2 or greater
- •No other serious medical or psychiatric illness
- •Not pregnant
- •Negative pregnancy test
- •Fertile patients must use effective contraception
- •PRIOR CONCURRENT THERAPY:
- •Biologic therapy:
- •Not specified
- •Chemotherapy:
- •See Disease Characteristics
- •No more than 2 prior regimens for recurrent disease, including 1 non-platinum containing regimen
- •At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas and mitomycin) and recovered
- •Endocrine therapy:
- •At least 1 week since prior hormonal therapy directed at primary tumor
- •Concurrent hormone replacement therapy allowed
- •Radiotherapy:
- •Not specified
- •See Disease Characteristics
- •At least 2 weeks since prior major surgery
排除标准
- 未提供