Establishment of a calibration sample for the evaluation of MRI perfusion measurement of cerebral blood flow at the individual case level: further development of the imaging-based differential diagnosis of dementia syndromes

Recruiting

• Conditions: The scientific question of the described research programme deals with the improvement of the early diagnosis of neurodegenerative diseases, especially dementia, through the further development and use of multimodal PET/MRI imaging techniques. The main aim of the project is to increase diagnostic accuracy and efficiency in order to enable more valid and reliable identification of patients with incipient memory impairment, particularly in relation to Alzheimer's disease.

• Registration Number: DRKS00033740
• Lead Sponsor: Klinik für Nuklearmedizin, Universitätsklinikum Ulm

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

Age: between 50-80 years
Absence of neurological or psychiatric disorders,
especially epilepsy, migraine, chronic tension headaches
Absence of severe or chronic physical illness
Absence of use of psychotropic substances
Absence of pregnancy
High-grade stenosis of the neck vessels (>70 %)

Exclusion Criteria

MRI exclusion criteria:
- Hydrocephalus shunt
- Metal implants in the head and/or body
- Condition after severe craniocerebral trauma or after surgery for brain tumours brain tumours
- Pacemaker
- Absence of a declaration of consent

Exclusion criteria for 18(F)-FDG PET examination:
- The blood glucose level is determined before the FDG injection. In case of
hyperglycaemia, FDG uptake may be reduced. If the
glucose level is above 150-200 mg/dl, the examination cannot be performed or
or at a later time after the glucose level has been checked again.
- Presence of pregnancy
- Because the FDG-PET examination is performed in the magnetic field of the
PET /MRI device, all MRI-related exclusion criteria also apply (see
exclusion criteria also apply (see above).

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between F-18 FDG-PET activity and ASL perfusion

Secondary Outcome Measures

Name	Time	Method
Differences between the sexes and the age decades