Effect of Guided Imagery on Well-being in Patients With Multiple Sclerosis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Quality of Life (MS-QOL-54)
Study Overview
Brief Summary
This single-center interventional study quasi-randomly allocated patients to a guided imagery or control intervention (positive journaling). Data were analyzed with treatment allocation masked.
Detailed Description
Interventions: Participants were assigned in alternate order to 10 weekly 1-hour sessions "Healing Light Guided Imagery" or at-home positive journaling; drop-outs were replaced.
Intervention Type: Behavioral
Multiple sclerosis (MS) is an autoimmune disease that affects the brain and spinal cord (central nervous system). Because nerves in any part of the brain or spinal cord may be damaged, patients with multiple sclerosis can have symptoms in different parts of the body. Many Multiple Sclerosis patients suffer from depression, fatigue and anxiety in addition to physical symptoms. Drugs prescribed for MS have been shown to not improve these comorbid psychological symptoms. Researchers have shown that mindfulness-based training programs can help MS patients, but these therapies are highly resource demanding and taxing for those involved. "Healing Light" Guided Imagery (HLGI; supplementary materials) is a guided imagery therapy that simulates a self-hypnotic trance state that has been anecdotally shown to improve depression and fatigue in patients with MS in less time and with fewer support resources. The investigators plan to test whether HLGI can increase patient well-being.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diagnosis of Relapsing-Remitting Multiple Sclerosis
- •18-70 years old
- •Able to read and write in English
- •Able to attend sessions at the UC San Diego School of Medicine
- •Age group: adult
- •Gender: both
- •Target enrollment: 20
- •Participant
Exclusion Criteria
- •Severe depression (score of 31 or higher on the BDI)
- •Very high levels of fatigue (above an average of 6 on the FSS)
- •Low levels of mindfulness (below an average score of 2 on the FMI).
Arms & Interventions
Guided Imagery
Guided Imagery meditation
Intervention: Guided Imagery (Other)
Journaling
Keeping a journal
Intervention: Journaling (Other)
Outcomes
Primary Outcomes
Quality of Life (MS-QOL-54)
Time Frame: Change from baseline at 10 weeks
Quality of Life based on Multiple Sclerosis Quality of Life Instrument (MS-QOL-54)
Secondary Outcomes
- Mood (BDI-II)(Change from baseline at 10 weeks)
- Fatigue (FSS)(Change from baseline at 10 weeks)
Investigators
Paul J. Mills
Professor
University of California, San Diego