Prospective Study on Patients With Obstructive Sleep Apnea in Hong Kong (PrOSA)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- incidence of Cardiovascular disease
研究概览
简要总结
Obstructive sleep apnea syndrome (OSAS) is a common disorder with prevalence rates of at least 4% among the middle-aged male Caucasians and Hong Kong (HK) Chinese populations. It is characterized by repetitive episodes of upper airway obstruction, causing intermittent hypoxia, sleep fragmentation, disabling daytime sleepiness, impaired cognitive function and poor health status. OSAS patients are at increased risks of non-fatal and fatal cardiovascular morbidity and mortality including sudden death, in addition to being more prone to road traffic accidents. However, there is no long term follow up of patients with OSAS on the incidence of cardiovascular disease, compliance on the therapy and the impact of the quality of life. The study is aimed to carry out a prospective observational study assessing the role of OSAS as a possible cause of increased cardiovascular risk and cognitive decline.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •suspected obstructive sleep apnea syndrome
- •aged 18 or above
- •must be able to speak, read and understand Chinese or English
- •possess the ability to respond to questions and follow instructions.
排除标准
- •already treated sleep apnea,
- •a limited life expectancy due to illness unrelated to sleep apnea
- •human immunodeficiency virus (HIV),
- •advanced renal disease,
- •uncontrolled malignancies
- •documented alcohol or drug abuse up to 1 year prior to inclusion in the study.
结局指标
主要结局
incidence of Cardiovascular disease
时间窗: 5 years
次要结局
- Change of Epworth Sleepiness Score(5 years)
- Change of Montreal Cognitive Assessment score (MoCA)(5 years)
研究者
Susanna SS Ng
Assistant Professor
Chinese University of Hong Kong