Metaplasticity in the Human Motor Cortex: Validation of an Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University of New Mexico
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Percent Change in MEP Amplitude
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) in healthy human participants.
Detailed Description
The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) in healthy human participants. Our primary objective is to compare pre- and post-measures of cortical excitability before priming tDCS (anodal, cathodal or sham) \[M1\], directly after priming tDCS \[M2\], directly after inhibitory rTMS \[M3\], and 10 minutes after inhibitory rTMS \[M4\]. Our secondary objective is to evaluate the sensitivity of motor excitability outcome measures response to the noninvasive neurostimulation (e.g. rTMS and tDCS). We also aim to compare pre- and post- measures of cortical excitability after inhibitory and excitatory priming of the motor cortex, and to evaluate the sensitivity of motor outcome measures to changes in cortical plasticity.
Investigators
Sarah Pirio Richardson
Assistant Professor of Neurology
University of New Mexico
Eligibility Criteria
Inclusion Criteria
- •Must be at least 18 years of age (all genders, races, ethnicity)
- •Must have no current psychiatric or neurologic issues
- •Must not have any conditions listed in exclusion criteria
- •Must be fluent in English
Exclusion Criteria
- •History of major psychiatric illness
- •Actively using neuropsychoactive medication
- •Legal or mental incompetency
- •Substance use disorder, abuse or dependence, with active use within the last three months
- •Significant medical or neurological illness
- •Prior neurosurgical illness
- •Prior neurosurgical procedure
- •History of seizure
- •History of ECT or TMS treatment within the past there months
- •Presence of a pacemaker, implanted medical pump or device, metal plate, or metal object in skull or eye (including shunts, dental implants, facial tattoos with metallic ink)
Outcomes
Primary Outcomes
Percent Change in MEP Amplitude
Time Frame: assessed and reported throughout study completion pre- and post- intervention approximately 30 minutes
Percent Change in MEP amplitude over the first dorsal interosseous (FDI) muscle of the right hand
Secondary Outcomes
- Cortical Silent Period(tDCS + rTMS assessed and reported pre and post (approximately 10 minutes))
- Simple Reaction Time(The final outcome will be percent change in the reaction time from pre- to post- intervention.)