CTIS2024-510834-42-00进行中（未招募）1 期
Efficacy comparison of two doses of vitamin D3 in critically ill patients undergoing continuous renal replacement therapy - NephroD - NephroD_2021
niwersytecki Szpital Kliniczny W Opolu0 个研究点目标入组 138 人开始时间: 2024年7月8日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 138
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •Presence of at least one of the following indications for implementation of CRRT by CVVHDF or CVVHF (Clinical Practice Guideline for Acute Kidney Injury): replacement of non-functioning kidney function when acute kidney injury occurs; hyperkalemia; metabolic acidosis; pulmonary edema; complications of uremia (hemorrhagic diathesis, pericarditis) - hypervolaemia; -Renal function support (control of goiter, acid-base, ion balance), Organ failure score (SOFA) of at least 5 at the time of qualification for the study, Patient age >18 years, 25(OH)D3 serum concentration =12.5 ng/ml - test performed by the local laboratory of the participating hospital, Properly managed enteral nutrition (through a gastric tuber or orally) at any dose.
排除标准
- •Acute or advanced chronic liver failure (estimated by clinical presentation and biochemical markers: serum bilirubin, serum AST and ALT, high AST/ALT serum ratio, glycemia, INR value), Sarcoidosis, Risk of impaired intestinal absorption in critical illness associated with at least one of the mentioned: impaired intestinal motility and delayed gastric emptying, constipation, diarrhea, intestinal hypoperfusion in shock, intoxication with subsequent intestinal edema after fluid resuscitation, changes in the intestinal microbiome., Hypercalcemia (total calcium >11 mg/dL or >2,7mmol/L), Any parathyroid disease, KDIGO classification of end-stage renal disease, Patients undergoing plasmapheresis, extracorporeal membrane oxygenation (ECMO), extracorporeal carbon dioxide elimination (ECCO2R), Patients who, in the opinion of the investigator, do not have a good chance of surviving the 72 hour period after study entry, History of kidney stones or de novo renal calculi, Patient eligible for futile therapy avoidance protocol, Pregnancy
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