Evaluation of Autogenous Dentin Graft Versus Demineralized Freeze-Dried Bone Allograft in the Treatment of Class ΙΙ and ΙΙΙ Mandibular Furcation Defects
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Tanta University
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Bleeding on probing
Study Overview
Brief Summary
Randomized clinical and radiographic trial
Detailed Description
Evaluation of Autogenous Dentin Graft versus Demineralized Freeze-Dried Bone Allograft in the Treatment of Class ΙΙ and ΙΙΙ Mandibular Furcation Defects
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 35 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Presence of class II and/or ΙΙΙ furcation defects in mandibular first or second molars according to criteria outlined by Hamp et. al.
- •Horizontal probing depth ≥3 mm using Naber's probe.
- •Clinical attachment level ≥3 mm measured from cemento-enamel junction (CEJ) till the deepest probing depth.
- •Evidence of radiolucency in the furcation area on panoramic radiograph.
- •Patients who will be assigned for groups (I and II) should present with teeth required for extraction due to advanced periodontal bone loss or other indications such as hopeless wisdom teeth or orthodontic indications or unrestorable fractured teeth as a source for autogenous dentin graft (ADG).
Exclusion Criteria
- •Medically compromised patients and systemic conditions precluding periodontal surgery.
- •Mandibular first or second molars with root caries or endodontic treatment.
- •Smokers, diabetics, pregnant or lactating women.
- •History of chemotherapy, radiotherapy in head and/or neck region.
- •Bisphosphonate therapy.
Arms & Interventions
Group 1 Subgroup B
Grade II furcation involvement treated with demineralized freeze-dried bone allograft
Intervention: (guided tissue regeneration) (Procedure)
Group II subgroup A
Grade III furcation involvement treated with Autogenous dentin graft
Intervention: (guided tissue regeneration) (Procedure)
Group 1 subgroup A
Grade II furcation involvement treated with autogenous dentin graft
Intervention: (guided tissue regeneration) (Procedure)
Group II subgroup B
Grade III furcation involvement treated with demineralized freeze-dried bone allograft
Intervention: (guided tissue regeneration) (Procedure)
Outcomes
Primary Outcomes
Bleeding on probing
Time Frame: Measured at baseline, 6 months and 12 months
According to Ramfjord, the bleeding at each site observed after probing and recorded positive if bleeding was observed within 30 seconds, if not was recorded as negative.
Probing pocket depth
Time Frame: Measured at baseline, 6 months and 12 months
According to Ramfjord, clinical parameter measured by UNC periodontal probe from a fixed point to the deepest probing depth. Using stent to standardize the measurements.
Clinical attachment level
Time Frame: Measured at baseline, 6 months and 12 months
According to Ramfjord, clinical parameter measured by a Naber\'s probe. Using stent to standard measurements.
Secondary Outcomes
- Radiographic outcome(measured at baseline and 1 year follow up)
Investigators
Banan Lotfy Mohamed Amer
Assistant lecturer at periodontology department, Principal Investigator, MSC
Tanta University