Effects of Chest Physiotherapy (CPT) on Lung Clearance Index (LCI) in Non Cystic Fibrosis (CF) Bronchiectasis

Not Applicable

Completed

• Conditions: Bronchiectasis
• Interventions: Other: Autogenic drainage

• Registration Number: NCT02411981
• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Brief Summary

This study will investigate the effects of on technique of chest physiotherapy on pulmonary function. Effects of pulmonary function will be measured by the spirometry, body plethysmography and by the multiple breath nitrogen washout technique.

Detailed Description

This is a before-after intervention study.

Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured before the application of chest physiotherapy.

The chest physiotherapy technique used will be autogenic drainage during 30 minutes. A resting period of 5 minutes will be given to the participant before the following tests.

Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured again, in the same order, after the application of chest physiotherapy.

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2015-04-03
• Study First Submitted QC: 2015-04-07
• Study First Posted: 2015-04-08
• Primary Completion: 2015-10
• Study Completion: 2016-02
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-19
• Last Update Posted: 2016-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Non cystic fibrosis bronchiectasis in stable state

Exclusion Criteria

• Not in stable state
• Bronchiectasis with severe respiratory morbidities likely to reduce the chest physiotherapy session efficacy (e.g. : severe chronic obstructive pulmonary disease)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Autogenic drainage	Autogenic drainage	The autogenic drainage will be the chest physiotherapy technique used for this study. Autogenic drainage is an airway clearance technique that attempts to obtain the optimal airflow to evacuate the secretions. This technique uses modulation of inspiratory and expiratory airflow at different breathing level within the vital capacity.

Primary Outcome Measures

Name	Time	Method
Change of Lung Clearance Index (LCI)	up to 80 minutes	LCI will me measured before and after the chest physiotherapy session

Secondary Outcome Measures

Name	Time	Method
Sputum weight	35 minutes	Sputum will be collected during the 30 minutes of chest physiotherapy session and 5 minutes immediately after. Sputum weight will be measured and correlated with change of LCI and spirometry values
Change of Spirometry	up to 40 minutes	Forced expired volume in one second (FEV1) and Forced expired flow at 25-75% of the forced vital capacity (FEF25-75) will be measured before and after the chest physiotherapy session

Trial Locations

Locations (1)

Cliniques universitaires Saint-Luc; 🇧🇪 Brussels, Belgium