Validation of a Non-Invasive Intracranial Pressure (ICP) Device by Comparison With Implanted Intracranial Pressure Monitoring Instrumentation or Lumbar Puncture
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intracranial Hypertension
- Sponsor
- Boston Neurosciences
- Enrollment
- 80
- Locations
- 4
- Primary Endpoint
- Non-invasive intracranial pressure (ICP) value
- Last Updated
- 7 years ago
Overview
Brief Summary
For purposes of validation, this study compares intracranial pressure measurements obtained with a novel self-calibrating, non-invasive, intracranial pressure measuring (ICP) device, with the values obtained from (a) patients in an intensive care unit (ICU) whose meet standard clinical indications for ICP measurement and whose ICP is measured using gold-standard implanted intracranial instrumentation and in (b) ambulatory subjects who meet clinical indications for lumbar puncture.
Detailed Description
This study is designed to validate intracranial pressure measurements obtained with a novel, self-calibrating, non-invasive, intracranial pressure measuring (ICP) device based on trans-cranial Doppler technology. The ophthalmic artery is utilized as a natural ICP sensor. Up to 80 subjects will be recruited in 4 centers to achieve a power of 90% and a p\<0.05 compared to the values obtained from (a) patients in an ICU whose meet standard clinical indications for ICP measurement and whose ICP is measured using gold-standard implanted intracranial instrumentation and in (b) ambulatory subjects who meet clinical indications for lumbar puncture. At least two comparative readings, separated by an hour or more, will be obtained from each subject.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ICU patients suspected of having an abnormality of ICP undergoing monitoring with commercially-available, FDA-approved instrumentation.
Exclusion Criteria
- •History of:
- •Glaucoma or optic hypertension
- •Severe orbital or ophthalmic injury
- •Orbital or intraocular surgery that might interfere with orbital compliance
- •Congenital malformations of the eye and/or orbit that might interfere with orbital compliance or orbital vascular anatomy
Outcomes
Primary Outcomes
Non-invasive intracranial pressure (ICP) value
Time Frame: Up to 5 days after admission to ICU
ICP value measured using novel non-invasive measurement device
Second non-invasive intracranial pressure (ICP) value
Time Frame: Up to 6 days after admission to ICU
A second measurement of ICP using novel non-invasive ICP measurement device