Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on miRNome in Gingival Tissues
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Probing Pocket Depth
研究概览
简要总结
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on miRNome in gingival crevicular fluid
详细描述
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment in subjects with periodontitis.
60 patients: 30 with periodontitis and 30 healthy controls. All the patients are assessed for clinical, periodontal, blood following of minimally invasive approach MINST or Q-SI (quadrantwise).
Measurements are taken before and after initial periodontal treatment in the periodontal subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Sealed envelopes
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of Periodontitis
排除标准
- •Periodontal treatment
- •Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
- •Pregnancy
研究组 & 干预措施
MINST non surgical periodontal treatment
Periodontitis patients treated by means of MINST. Patients were treated with non-surgical MINST periodontal treatment in a single session.
干预措施: Probin Pocket Depth reduction (Other)
Q-SI non surgical periodontal treatment
Periodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week.
干预措施: Probin Pocket Depth reduction (Other)
结局指标
主要结局
Probing Pocket Depth
时间窗: 6-months
Reduction in Probing Pocket Depth after treatnebt
次要结局
未报告次要终点
研究者
Gaetano Isola
Associate Professor
University of Catania