Characterization of Corticospinal Excitability During Progressive Skin Cooling
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Change in Corticospinal Excitability
研究概览
简要总结
This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.
详细描述
Cold stress is known to impair both fine and gross motor movement. Reductions in performance may have life threatening consequences in survival situations where maintenance of muscle control is necessary. Much of the effects cooling has on muscle performance is directly due to its effects on muscle tissue itself, whereas less is known about the effects on the central nervous system. Therefore, the purpose of the study was to characterize corticospinal excitability that accompanies basic cold stress via progressive skin cooling, resulting in reductions in skin (Tsk) or core (Tco) temperature and shivering.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult
- •Right Handed
- •Pass Magnetic Stimulation Safety Checklist
- •Pass Medical Screening Questionnaire
排除标准
- •Left Handed
- •Any adverse responses to cold exposure (Raynaud's Syndrome)
- •Cardiorespiratory Disease
结局指标
主要结局
Change in Corticospinal Excitability
时间窗: at 0, 20, 40, 60 and 90 minutes
Motor Evoked Potentials (MEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of Corticospinal excitbaility
次要结局
- Change in Skin Temperature(at 0, 20, 40, 60 and 90 minutes)
- Change in Spinal Excitability(at 0, 20, 40, 60 and 90 minutes)
- Change in Core Temperature(at 0, 20, 40, 60 and 90 minutes)
- Change in Metabolic Heat Production(at 0, 20, 40, 60 and 90 minutes)
研究者
Dr.Gordon Giesbrecht
Professor
University of Manitoba