Determinants of Cerebral Oxygenation and Perfusion in SCA Children Based on Combined ASL MRI, NIRS and Hemorheological Investigation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 64
- 试验地点
- 2
- 主要终点
- Number of patients on which we detect default of cerebral perfusion (in order to correlate them with other clinical or biological parameters)
研究概览
简要总结
The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling (ASL) perfusion MR (Magnetic Resonnance) imaging, brain Near Infra-Red Spectroscopy (NIRS) and red blood cell (RBC) rheological properties.
详细描述
The investigators hypothesize that brain perfusion and/or oxygenation modifications may be evidenced in SCA children who have no microarteriopathy and may correlate with hemorheological abnormalities and impaired vasomotion. A multimodal approach designed to study a. cerebral perfusion and oxygenation, b. flow motion properties and c. blood rheological parameters might help to describe the different processes involved in cerebral ischemia.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SS or S-beta° genotype;
- •age 6-16 years;
- •steady state;
- •normal TCD (Transcranial Doppler);
- •parental study approval and written informed consent.
排除标准
- •SC, Sbeta+, SD Punjab genotype
- •history of overt stroke,
- •intracranial or cervical arterial stenosis,
- •abnormal TCD at the time of the study.
结局指标
主要结局
Number of patients on which we detect default of cerebral perfusion (in order to correlate them with other clinical or biological parameters)
时间窗: 1.5 years
ASL sequence (duration 4 min) : Regional brain tissue perfusion (expressed in mL/min/100g of tissue) will be measured in different lobes in both hemispheres and in the cerebellum. Pattern of perfusion will be analysed and measured.
次要结局
- Bifrontal cerebral hemoglobin oxygen saturation(1.5 years)
- Description of the global assessment of RBC deformability(1.5 years)