Effect of Resistance Training Variable Manipulation (Intensity and Volume) on Body Composition, Fatigability and Functional Capacity in Postmenopausal Breast Cancer Survivors.
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Evaluation the Fatigability
研究概览
简要总结
This study intends to evaluate the impact of resistance training variable manipulation (intensity and volume) on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.
详细描述
The treatment for breast cancer (chemotherapy, radiotherapy and hormone therapy) provokes collateral effects,such as muscle mass and strength losses, increase of fat mass, fatigue and disability and reduced quality of life in postmenopausal breast cancer survivors. The resistance training is assumed as a non-pharmacologic interventions in postmenopausal breast cancer survivors. However, it is unclear whether the manipulation of training variables (intensity and volume) maximize the effects of resistance training on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Postmenopausal breast cancer survivors;
- •No supervised or unsupervised exercise at least for six months prior to the study.
排除标准
- •Alcoholics;
- •No controlled blood pressure and glucose;
- •Presence of myopathies, arthropathies, and neuropathies;
- •Presence of muscle, thromboembolic and gastrointestinal disorders, infection diseases.
研究组 & 干预措施
Control group, CT
In the CT, the postmenopausal breast cancer survivers does not perform exercise.
干预措施: Control group (Other)
Lower-load resistance training (LL)
In the LL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with low loads ( i.e. three sets with 30% of one-repetition maximum).
干预措施: Lower-load resistance training (LL) (Other)
Higher-load resistance training (HL)
In the HL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with high loads (i.e. three sets with 80% of one maximum repetition).
干预措施: Higher-load resistance training (HL) (Other)
Higher-volume resistance training (HV)
In the HV, the postmenopause breast cancer survivers will be submitted to 12 weeks of resistance training with high volume ( i.e. six sets with 80% one maximum repetition).
干预措施: Higher-volume resistance training (HV) (Other)
结局指标
主要结局
Evaluation the Fatigability
时间窗: pre and post intervention (i.e. 12 weeks)
The fatigability will be evaluate by 60 maximum voluntary isometric contractions (3 s contraction, 2 s rest) in knee extensors at 70 degree
次要结局
- Four- meter walk test(pre and post intervention (i.e. 12 weeks))
- Six Minutes-walk test (6MWT)(pre and post intervention (i.e. 12 weeks))
- Timed Up and Go test(pre and post intervention (i.e. 12 weeks))
- Fat mass(pre intervention and post intervention (i.e. 12 weeks))
- 10-meter walk test(pre and post intervention (i.e. 12 weeks))
- 400-meter walk test(pre and post intervention (i.e. 12 weeks))
- 900-meter walk test(pre and post intervention (i.e. 12 weeks))
- Muscle mass(pre and post intervention (i.e. 12 weeks))
- Muscle strength(pre and post intervention (i.e. 12 weeks))
- Five-times-sit-to-stand test(pre and post intervention (i.e. 12 weeks))
研究者
Fábio Lera Orsatti
Principal Investigator
Universidade Federal do Triangulo Mineiro