ISRCTN29594895
Active, not recruiting
未知
A randomised feasibility study evaluating the effect of perioperative intravenous lIdocaine on colorectal cancer outcome after surgery
Chelsea and Westminster Hospital0 sites50 target enrollmentApril 6, 2022
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Colorectal cancer patient undergoing surgery for cancer resection
- Sponsor
- Chelsea and Westminster Hospital
- Enrollment
- 50
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37387798/ (added 03/07/2023)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged 18 years and above, undergoing laparoscopic surgery with stage 2 or 3 colon cancer
- •2\. Ability and willingness to consent
Exclusion Criteria
- •1\. Stage 1 and stage 4 colon or rectal cancer
- •2\. Palliative surgery with no curative intent
- •3\. Extensive comorbidities, i.e. American Society of Anesthesiologists (ASA) Score IV
- •4\. Patients with known allergy to lidocaine
- •5\. Patients who are pregnant or breastfeeding
- •6\. Patients who are likely to have adverse effects from the accumulation of intravenous lidocaine:
- •6\.1\. Known liver disease with liver function outside the normal laboratory range
- •6\.2\. Epilepsy
- •6\.3\. Cardiac conduction abnormalities based on history and confirmed by electrocardiogram
Outcomes
Primary Outcomes
Not specified
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