Sex Differences in Relative Survival and Excess Mortality Following Acute Myocardial Infarction

Completed

• Conditions: Acute Myocardial Infarction
• Interventions: Other: Excess mortality

• Registration Number: NCT02952417
• Lead Sponsor: University of Leeds

Brief Summary

The aim of this study was to estimate the impact of sex on relative survival and excess mortality following acute myocardial infarction (AMI) using a population-based cohort within a relative survival framework. Patient-level data concerning demographics, co-morbidity, cardiovascular risk factors and treatments at discharge were extracted from the Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART), a population-based registry of outcomes for patients hospitalized with acute coronary syndrome. Patients were followed-up for their vital status after AMI hospitalisation, with censoring at the end of follow-up on the 31st of December, 2013.

Detailed Description

Details of SWEDEHEART and data validation have been described previously. Cases of acute myocardial infarction were defined as STEMI and NSTEMI according to the current European Society of Cardiology, American College of Cardiology and American Heart Association guidelines and determined at local level by the attending Consultant.

Study Timeline

• Study Start: 2003-12
• Primary Completion: 2013-12
• Study Completion: 2014-01
• Status Verified: 2016-10
• Study First Submitted: 2016-10-31
• Study First Submitted QC: 2016-11-01
• Last Update Submitted: 2016-11-01
• Study First Posted: 2016-11-02
• Last Update Posted: 2016-11-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 180000

Inclusion Criteria

• Patients were included if they are aged over 18 years who had been hospitalised following acute myocardial infarction between 1st January, 2003 and 31st December, 2013

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
STEMI and NSTEMI Women	Excess mortality	Women with ST-segment elevation myocardial infarction (STEMI) and women non-STEMI (NSTEMI) who survived following acute myocardial infarction and at risk of excess mortality.

Primary Outcome Measures

Name	Time	Method
Excess mortality rate ratio	10 years