The Association Between the Gut Microbiota Composition and Development of Delirium in ICU Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Delirium of Mixed Origin
- Sponsor
- Herlev Hospital
- Enrollment
- 50
- Primary Endpoint
- Gut Microbiota composition
- Last Updated
- 8 years ago
Overview
Brief Summary
To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.
Detailed Description
We plan to include an equal number of patients admitted to the ICU, that either do or don't develop delirium during their course of critical illness. Samples of feces/rectal swaps will be taken at admission and again either when the patients become CAM-ICU positive, alternatively after 5 days admssion/at discharge in patients that remain CAM-ICU negative. Samples are then sent to analyses for purification of bacterial DNA and metagenomic analysis.
Investigators
Anne Sofie Andreasen, MD, ph.d, EDIC
MD,PhD
Herlev Hospital
Eligibility Criteria
Inclusion Criteria
- •Admission to the ICU, Disability to make informed consent due to critical illness -
Exclusion Criteria
- •Dementia. Delirium diagnosed prior to the ICU admission on the non-ICU floors. Coma. Indication for deep sedation (-4/-5).
Outcomes
Primary Outcomes
Gut Microbiota composition
Time Frame: May 2018
Metagenomic analysis of Gut Microbiota / composition by different bacterial families