The Association Between the Gut Microbiota Composition and Development of Delirium in ICU Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 主要终点
- Gut Microbiota composition
研究概览
简要总结
To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.
详细描述
We plan to include an equal number of patients admitted to the ICU, that either do or don't develop delirium during their course of critical illness. Samples of feces/rectal swaps will be taken at admission and again either when the patients become CAM-ICU positive, alternatively after 5 days admssion/at discharge in patients that remain CAM-ICU negative.
Samples are then sent to analyses for purification of bacterial DNA and metagenomic analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Admission to the ICU, Disability to make informed consent due to critical illness -
排除标准
- •Dementia. Delirium diagnosed prior to the ICU admission on the non-ICU floors. Coma. Indication for deep sedation (-4/-5).
结局指标
主要结局
Gut Microbiota composition
时间窗: May 2018
Metagenomic analysis of Gut Microbiota / composition by different bacterial families
次要结局
未报告次要终点
研究者
Anne Sofie Andreasen, MD, ph.d, EDIC
MD,PhD
Herlev Hospital