TCTR20170206005Enrolling By Invitation未知
Effect of diltiazem on tacrolimus concentration in CYP3A5 expressers Thai kidney transplant recipients
适应症
试验速览
- 阶段
- 未知
- 状态
- Enrolling By Invitation
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 0 N/A (No limit)（—）
- 性别
- All
入选标准
- •1. First kidney transplantation
- •2. Living related kidney transplant patients
- •3. Being prescribed mycophenolate mofetil or mycophenate sodium, tacrolimus and prednisolone as maintenance immunosuppressive agent to prevent allograft rejection
排除标准
- •1. more than one organ transplantation
- •2. ABO incompatible transplantation
- •3. patients who require anti-thymocyte immunoglobulin for induction therapy
- •4. patients who receive concomitant drugs (other than methylprednisolone, prednisolone and omeprazole) that may affect CYP3A4 and P-glycoprotein activity
- •5. patients with history of cirrhosis, elevated liver enzyme more than 3x of upper limit normal (AST>100 U/L and ALT>120 U/L) or hepatitis C viral infection
- •6. active gastrointestinal disorder
- •7. anemia (Hb<9 g/dL)
- •8. hypoalbuminemia (Alb<3 g/dL)
- •9. blood preesure below 110/70 mmHg
- •10. fever or active infection
- •11. incomplete data in medication record and/or computer system
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