Association of Serum Folic Acid and Vitamin B12 levels with Follicle to Oocyte Index and Embryo Quality in Women undergoing IVF/ ICSI

This prospective cohort study aims to evaluate the association between serum folic acid and vitamin B12 levels with the follicle-to-oocyte index (FOI) and embryo quality in women undergoing IVF/ICSI. Conducted at VMMC & Safdarjung Hospital, New Delhi, over 18 months with 50 participants, the study involves dietary assessment, serum folic acid and vitamin B12 levels analysis, controlled ovarian stimulation, oocyte retrieval, and Day 3 embryo grading using ESHRE criteria. Given the limited literature on this topic, the study also explores correlations between dietary intake and serum levels of these micronutrients, aiming to identify potential modifiable factors that influence oocyte yield and embryo development in IVF/ICSI. If an association is found, supplementation with folic acid and vitamin B12 prior to IVF/ICSI may improve embryo quality and outcomes.