Evaluation of the risk of metachronous squamous cell carcinoma of the esophagus and the head and neck after endoscopic resection for squamous cell carcinoma of the esophagus according to genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2.
Not Applicable
- Conditions
- squamous cell carcinoma of the esophagus and the head and neck
- Registration Number
- JPRN-UMIN000019852
- Lead Sponsor
- Hokkaido University Graduate School of Medicine
- Brief Summary
Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 158
Inclusion Criteria
Not provided
Exclusion Criteria
1 Surgery was added. 2 Officer has determined to be inappropriate. 3 Less than 20 years old. 4 During pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of metachronous squamous cell carcinoma of the esophagus and the head and neck according to genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2.
- Secondary Outcome Measures
Name Time Method