A randomized controlled trial of jumbo biopsy versus cold snare for removal of diminutive polyps

Not Applicable

Completed

• Conditions: Diseases of the digestive system

• Registration Number: KCT0002805
• Lead Sponsor: The Catholic University of Korea, Incheon St. Mary's Hospital

Brief Summary

Background and Aims: Cold snare polypectomy (CSP) and jumbo forceps polypectomy (JFP) have been shown to be effective for removing diminutive colorectal polyps (DCPs) (_5 mm). However, no study has compared complete resection rates between CSP and JFP for DCPs. The aim of this study was to compare the efficacy and safety of JFP with CSP for the removal of DCPs. Methods: This was a prospective randomized controlled trial from 2 tertiary-care referral centers. A total of 1003 patients were screened, and 169 patients with 196 DCPs were enrolled. The main outcome was complete polyp resection rate. Results: Of 196 diminutive polyps, 177 (90.3%) were adenomatous polyps. The overall complete resection rate was 92.1% (163/177). The complete resection rate was not significantly different between JFP and CSP groups (92.0% vs 92.2%; P Z .947). JFP achieved complete resection rates comparable with CSP for polyps >3 mm (90.3% vs 89.8%; P Z .928). Polypectomy procedure time, tissue retrieval rate, and rate of postpolypectomy adverse events were not significantly different between the 2 groups. Conclusions: Both JFP and CSP achieved complete resection rates of >90% for DCPs. Thus, JFP may be considered for polypectomy of DCPs.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-10-31
• Last Update Posted: 28 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 124

Inclusion Criteria

Among the patients who underwent colonoscopy, less than 5 mm of polyps are found

Exclusion Criteria

1. Patients under the age of 18 years or over the age of 80 years
2. Patients taking antiplatelet or anticoagulation therapy within 5 days before undergoing colonoscopy
3. Patients with inflammatory bowel disease, polyposis syndrome, pregnancy, or an inability to provide informed consent

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biopsy was performed on the polypectomy site to determine whether residual lesion (complete resection)

Secondary Outcome Measures

Name	Time	Method
Complication and procedure time