Perioperative Duloxetine and Etoricoxib improve postoperative pai
Not Applicable
Completed
- Conditions
- SurgeryPostoperative pain after laminectomy surguries
- Registration Number
- ISRCTN48329522
- Lead Sponsor
- Al-Minia University
- Brief Summary
2017 results in https://pubmed.ncbi.nlm.nih.gov/29197345/ (added 26/11/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1. Patients with an ASA physical status of I, II and III scheduled for single level lumbar spinal disc prolapsed surgery
2. Can provide written informed consent
3. Aged between 18 and older
Exclusion Criteria
1. History of allergic reaction to any of the study drugs
2. History of drug or alcohol abuse
3. Abnormal renal or liver function tests.
4. Patients using antidepressants who did not stop taking them two weeks before surgery
5. Patients with previous cervical surgeries, psychiatric disorders and patients receiving opioid analgesic medications within 24 hours preoperatively
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain is measured using pain assessment measures and questions 30 minutes after the end of anesthesia and two, four, six, 12, 24 and 48 hours post-operatively
- Secondary Outcome Measures
Name Time Method <br> 1. The time to first rescue analgesic is routinely 24h and 48h postoperatively<br> 2. Total morphine consumption is measured by calculating the doses at 24 and 48 hours post-operatively<br> 3. Side effects, including headache, rash, nausea, vomiting, dizziness and drowsiness are recorded. The severity of postoperative nausea and vomiting (PONV) is graded on a four-point ordinal scale<br> 4. Patient satisfaction is measured using a numerical rating scale (NRS) at 24 hours post-operatively<br>