NCT04825158Unknown不适用
Study of the Role of Hemostasis in Perioperative Anaphylaxis
University Hospital, Strasbourg, France0 个研究点目标入组 30 人开始时间: 2021年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 主要终点
- Platelet activation
研究概览
简要总结
Anaphylaxis is a severe and life-threatening complication during the perioperative period. Perioperative anaphylaxis is still associated with a significant mortality despite quick and efficient management using epinephrine, the mainstay of acute treatment. Experimental data and few case reports are suggesting that hemostasis, and more precisely platelets, could play a role in anaphylaxis. Our main hypothesis is that activation of the hemostatic system contributes to the severity of the reaction
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient, male or female, adult
- •In the perioperative period
- •In whom the diagnosis of anaphylactic shock is suggested
- •Patient is giving his consent to participate in the study
排除标准
- •Subject under legal protection
- •Subject under guardianship or guardianship
- •Anemia less than 7 g /dl at the time of inclusion
结局指标
主要结局
Platelet activation
时间窗: During the allergic workup (4-6 weeks after)
Measurement of: Plasmatic serotonin level, Plasmatic PF-4 level, P-selectin expression (MFI, %), Platelet count
次要结局
未报告次要终点
研究者
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