Study of the Role of Hemostasis in Perioperative Anaphylaxis

• Conditions: Perioperative Complication; Hemoptysis; Anaphylaxis

• Registration Number: NCT04825158
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Anaphylaxis is a severe and life-threatening complication during the perioperative period. Perioperative anaphylaxis is still associated with a significant mortality despite quick and efficient management using epinephrine, the mainstay of acute treatment. Experimental data and few case reports are suggesting that hemostasis, and more precisely platelets, could play a role in anaphylaxis. Our main hypothesis is that activation of the hemostatic system contributes to the severity of the reaction

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-21
• Status Verified: 2021-03
• Study First Submitted QC: 2021-03-30
• Last Update Submitted: 2021-03-30
• Study Start: 2021-04-01
• Primary Completion: 2021-04-01
• Study First Posted: 2021-04-01
• Last Update Posted: 2021-04-01
• Study Completion: 2024-02-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patient, male or female, adult
• In the perioperative period
• In whom the diagnosis of anaphylactic shock is suggested
• Patient is giving his consent to participate in the study

Exclusion Criteria

• Subject under legal protection
• Subject under guardianship or guardianship
• Anemia less than 7 g /dl at the time of inclusion

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Platelet activation	During the allergic workup (4-6 weeks after)	Measurement of: Plasmatic serotonin level, Plasmatic PF-4 level, P-selectin expression (MFI, %), Platelet count