Effects of psychosocial stress and performance feedback on pain processing and its neuroendocrine mediatio
Not Applicable
- Conditions
- R52.0Acute pain
- Registration Number
- DRKS00026946
- Lead Sponsor
- niversität Würzburg Institut für Psychologie Fakultät für Humanwissenschaften
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 179
Inclusion Criteria
gender: female
- between 18 and 35 years old
- being fluent in German
Exclusion Criteria
- psychopharmacological or analgesic medication
- regular smoking
- mental disorders
- acute or chronic pain
- being a psychology student for more than two semesters
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim was to show potential changes in different pain variables, which were assessed during the experimental procedure four minutes post-TSST (partly in combination with feedback of different valence) and post-recovery (approximately 40 minutes after performing the TSST). A baseline measurement was also collected at the beginning of the experiment as a reference. Pain measurement was based on phasic or tonic heat pain stimuli and can be described as multidimensional, meaning that different pain tests were measured using a thermode (heat pain threshold, heat pain tolerance, temporal summation, ratings of phasic heat pain stimuli) or a combination of the hot water bath circulator and the thermode (conditioned pain modulation of heat pain threshold and ratings of phasic heat pain stimuli). Each pain measurement took approximately 15 minutes.
- Secondary Outcome Measures
Name Time Method Potential influences of subjective and physiological stress parameters on changes in pain perception were to be recorded. For this purpose, stress ratings and anxiety scores were asked at different measurement points during the experiment. In addition, salivary cortisol and salivary alpha-amylase were determined as objective stress markers. Saliva was collected via salivettes, which were analyzed in a special laboratory. The physiological peaks of these direct (cortisol) or indirect (alpha-amylase as a non-invasive substitute for the determination of catecholamine activity) hormonal parameters were taken into account. Correlations of the subjective parameters post-TSST or the peaks of objective stress parameters were calculated, besides, the time courses of all parameters enumerated here were also used as manipulation checks.