The effect of vitamin C from kiwifruit on human immune cell functio

Not Applicable

Completed

• Conditions: Vitamin C nutritional status; Immune health; Inflammatory and Immune System - Normal development and function of the immune system; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12621000755831
• Lead Sponsor: niversity of Otago, Christchurch

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-16
• Study Completion: 2021-12-17
• Last Update Posted: 26 September 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Inclusion criteria (all required): Males or females 18-65 years; Plasma vitamin C levels <40 µmol/L at baseline.

Exclusion Criteria

Exclusion criteria (one required); Taking prescription medication (within past three months); Allergy/intolerance to kiwifruit; Daily smoker: Taking vitamin C supplements (within past three months); High fruit/juice & vegetable consumption (5 or more servings/day); Excessive alcohol consumption (more than 21 standard drinks/week); Diabetes mellitus; Bleeding disorders; Fear of needles.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cytokine release by peripheral blood mononuclear cells in response to inflammatory challenge, before and after intervention..[At baseline and four weeks post-intervention.];Vitamin C levels in peripheral blood mononuclear cells[At baseline, at trial midpoint (2 weeks post-intervention) and 4 weeks post intervention.];Plasma vitamin C status[At baseline, at midpoint (2 weeks post-interventions) and at 4 weeks post intervention.]

Secondary Outcome Measures

Name	Time	Method
Determination of changes in gene expression in a subset of peripheral blood mononuclear cell samples following kiwifruit intake. [At baseline and 4 weeks post-intervention];Effect of kiwifruit intervention on susceptibility to respiratory illness, monitored by symptom survey.[Up to 12 weeks beyond the end of intervention period.]