GnRH Agonist Administration in the Luteal Phase of ICSI-ET Cycles
- Registration Number
- NCT00516490
- Lead Sponsor
- V.K.V. American Hospital, Istanbul
- Brief Summary
A single dose GnRH agonist administration in the luteal phase of assisted reproduction cycles was reported to increase pregnancy and birth rates. This study was done to evaluate the reproducibility of previous findings.
- Detailed Description
GnRH agonist administration in the luteal phase was reported to beneficially affect clinical outcome of ICSI-ET cycles. This randomized controlled trial evaluates the effect of a single dose GnRH agonist administered in the luteal phase on the outcome of ICSI - ET cycles stimulated with the long GnRH agonist protocol. Women undergoing embryo transfer following controlled ovarian hyperstimulation with a long GnRH agonist protocol were included. In addition to routine luteal phase support with progesterone women were randomized to receive a single dose of GnRH agonist or placebo on the sixth day after ICSI.Ongoing pregnancy rate was the primary outcome measure.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 570
- Women undergoing embryo transfer following controlled ovarian hyperstimulation with a long GnRH agonist protocol, oocyte pick-up and ICSI.
- Embryo transfer performed on day 3.
- Participation in another trial that was being conducted in our unit at the same time.
- Preimplantation genetic screening cycles.
- Day 5 embryo transfers.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Na Cl %0.9 Sterile saline injection 1 triptorelin acetate GnRH agonist administration
- Primary Outcome Measures
Name Time Method Ongoing pregnancy rate beyond 20 weeks
- Secondary Outcome Measures
Name Time Method Embryo implantation rate Clinical pregnancy
Trial Locations
- Locations (1)
Amerikan Hastanesi Tüp Bebek Merkezi
🇹🇷Istanbul, Turkey