GnRH Agonist Administration in the Luteal Phase of ICSI-ET Cycles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 570
- 试验地点
- 1
- 主要终点
- Ongoing pregnancy rate beyond 20 weeks
研究概览
简要总结
A single dose GnRH agonist administration in the luteal phase of assisted reproduction cycles was reported to increase pregnancy and birth rates. This study was done to evaluate the reproducibility of previous findings.
详细描述
GnRH agonist administration in the luteal phase was reported to beneficially affect clinical outcome of ICSI-ET cycles. This randomized controlled trial evaluates the effect of a single dose GnRH agonist administered in the luteal phase on the outcome of ICSI - ET cycles stimulated with the long GnRH agonist protocol. Women undergoing embryo transfer following controlled ovarian hyperstimulation with a long GnRH agonist protocol were included. In addition to routine luteal phase support with progesterone women were randomized to receive a single dose of GnRH agonist or placebo on the sixth day after ICSI.Ongoing pregnancy rate was the primary outcome measure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women undergoing embryo transfer following controlled ovarian hyperstimulation with a long GnRH agonist protocol, oocyte pick-up and ICSI.
- •Embryo transfer performed on day 3.
排除标准
- •Participation in another trial that was being conducted in our unit at the same time.
- •Preimplantation genetic screening cycles.
- •Day 5 embryo transfers.
研究组 & 干预措施
1
GnRH agonist administration
干预措施: triptorelin acetate (Drug)
2
Sterile saline injection
干预措施: Na Cl %0.9 (Drug)
结局指标
主要结局
Ongoing pregnancy rate beyond 20 weeks
次要结局
- Embryo implantation rate
- Clinical pregnancy