eural plasticity and recovery after early and intensive upper extremity motor training in people with cervical spinal cord injury.

Conditions: Spinal Cord Injury
tetraplegia
10041543

Registration Number: NL-OMON53224

Lead Sponsor: niversiteit Hasselt

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 15

Inclusion Criteria

Traumatic or non-traumatic C-SCI in the preceding 13 weeks;
age over 16 years; have an incomplete SCI or an AIS A SCI with zones of partial
motor paralysis (as defined
by the International Standards for the Neurological Classification of SCI
(ISNCI) and medically stable.

Exclusion Criteria

SCI with ASIA Impairment Scale (AIS) A without zones of
partial preservation (decided based on former studies [58]) and expertise of
the team; SCI with any significant medical condition that could prevent the
person from participating. In order to ensure TMS measurement can be performed,
patients will only be included in this WP if they have a positive response to
motor evoked potential measurement (MEP+) [59] and will be excluded in the
presence of contraindications for TMS application such as epilepsy, metal
implants in the brain, defibrillator, pacemaker and pregnancy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Central plasticity via: Single pulse TMS (cortical mapping and rest motor<br /><br>threshold) 8 weken after randomisation</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Klinische maten: Upper Extremity Motor Score, Spinal Cord Independence Measure<br /><br>(SClM-zelfzorg); Van Lieshout Test (VLT); Grades redefined assessment of<br /><br>strength sensibility and Prehension (GRASSP); Hand-Held Dynamometrie;<br /><br>accelerometrie (sessie densiteit: actievetherapietijd/sessie lengte); ervaring<br /><br>moeilijkheid en ervaring intensiteit.<br /><br>Centrale plasticiteit: Paired pulse TMS: (SICI; LICI; SICF); perifere<br /><br>plasticiteit: NET (Nerve excitability testing) en MScanFit MUNE (Compound<br /><br>muscle action potential (CMAP).</p><br>