Study of the Clinical Effect of External Oblique Muscle Intercostal Muscle Plane Block in Abdominal Surgery

Not Applicable

Completed

• Conditions: Nerve Block; Pain

• Registration Number: NCT06684210
• Lead Sponsor: The First Hospital of Qinhuangdao

Brief Summary

This study intends to apply external oblique intercostal muscle plane block in thoracoabdominal resection, and to explore its effect on perioperative analgesia and rehabilitation quality in patients undergoing thoracoabdominal surgery.

Detailed Description

Approved by the hospital ethics committee, 60 patients undergoing thoracic and abdominal surgery were selected in this study. They were divided into experimental group (n=30) and control group (n=30). The experimental group was given 0.5% ropivacaine intercostal nerve block, 2.0ug/kg sufentanil and tropisetron 5mg intravenous analgesia, and the control group was given 2.0ug/kg sufentanil and tropisetron 5mg intravenous analgesia. MAP, HR and SPO2 were recorded at admission (T0), completion of induction (T1), skin incision (T2), 30min after operation (T3) and 30min after extubation (T5). The block range of nerve block in the experimental group was recorded. The VAS score and the number of patient-controlled analgesia pump were recorded 30min after extubation, 6h, 24h and 48h after operation in resting state and cough state. Postoperative adverse reactions such as respiratory depression, expectoration weakness, nausea, vomiting, and skin itching were recorded. The first time to get out of bed after operation was recorded.

Study Timeline

• Study Start: 2023-03-01
• Primary Completion: 2024-01-01
• Study Completion: 2024-02-01
• Study First Submitted: 2024-10-17
• Status Verified: 2024-11
• Study First Submitted QC: 2024-11-08
• Last Update Submitted: 2024-11-08
• Study First Posted: 2024-11-12
• Last Update Posted: 2024-11-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA Physical Status Classification of I-II Aged 18-60 years old ; Will be scheduled to undergo elective LC

Exclusion Criteria

• Coagulation disorders, Liver/kidney disease, Abdominal surgery history, Infection in the block application area, Chronic opioid use.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Patient's postoperative pain score	Extubation for 30minutes, 6 hours after surgery, 24 hours after surgery, and 48 hours after surgery	Using the VIsual Analogue Scale,patients were guided to indicate the corresponding pain score according to their own pain situation, and the score ranged from 0 to 10. To evaluate the degree of postoperative pain, a score of 0 indicates no pain at all, a score of 2 indicates mild pain, and a score of 10 indicates the most severe pain, with higher scores indicating more severe pain

Secondary Outcome Measures

Name	Time	Method
Changes in blood pressure	Perioperative period	Mean arterial pressure at different time points.Mean arterial pressure will be reported in mmHg.
Changes in heart rate	Perioperative period	Heart rate at different time points.Heart rate will be reported in counts per minute.
Extent of action of external oblique intercostal muscle plane block	Ten minutes after the nerve block	The specific extent of action of the external oblique muscle intercostal muscle plane block in the thoracoabdominal wall.

Trial Locations

Locations (1)

The first hospital of Qinhuangdao; 🇨🇳 Qinhuangdao, Hebei, China