COVID-19: Nasal and Salivary Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses: Double-blind, Randomized, Placebo-controlled Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 176
- 试验地点
- 8
- 主要终点
- Change from Baseline amount of SARS-CoV-2 in salivary samples at 7 days
研究概览
简要总结
Given the current lack of effective COVID-19 treatment, it is necessary to explore alternative methods to contain the spread of the infection, focusing in particular on its mode of transmission. The modes of person-to-person transmission of SARS-CoV-2 are direct transmission, such as sneezing, coughing, transmission through inhalation of small droplets, and transmission through contact, such as contact with nasal, oral and eye mucous membranes. SARS-CoV-2 can also be transmitted directly or indirectly through saliva. The use of antiviral mouthrinses may be used as adjunctive therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of Covid-19 infection by the patient's general practitioner and hospital doctor
- •Clinical signs started less than 8 days ago.
- •Virological confirmation
- •Understanding and acceptance of the trial.
- •Written agreement to participate in the trial
排除标准
- •Pregnancy
- •Breastfeeding
- •Inability to comply with protocol
- •Lack of written agreement
结局指标
主要结局
Change from Baseline amount of SARS-CoV-2 in salivary samples at 7 days
时间窗: 7 days
Quantitative PCR experiments will be performed and a quantitative analysis of the salivary samples will be made
次要结局
- Change from Baseline amount of SARS-CoV-2 virus in nasal samples at 7 days(7 days)
研究者
Carrouel Florence
Associate professor
Claude Bernard University