NCT02081898已完成3 期
Three-year Mild Calorie Restriction Partially Protects Against Age-related Increase in Sphingomyelin and Reduces Obesity-associated Amino Acids
适应症
干预措施
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- anthropometry
研究概览
简要总结
The effect of weight loss with long-term low calorie diet (LCD) on plasma metabolites is unknown. The aim was to examine whether a LCD-induced weight reduction results in changes in the extended plasma metabolites.
详细描述
Overweight/obese subjects (25≤ BMI <33 kg/m2) aged 40 to 59 years consumed a LCD (an approximate 100 kcal/day calorie deficit) or a weight-maintenance diet (control) in a randomized, controlled design with 3-year intervention period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •25 <= BMI < 33 kg/m2
排除标准
- •type 2 diabetes
- •cardiovascular disease
- •psychiatric problems
- •any medication use
研究组 & 干预措施
control group
No Intervention
weight maintenance diet
low calorie diet (LCD) group
Experimental
approximate 100 kcal/d calorie deficit
干预措施: LCD (Dietary Supplement)
结局指标
主要结局
anthropometry
时间窗: 3-year follow-up
weight, height, BMI, waist circumference, blood pressure
次要结局
- biochemistry analysis(3-year follow-up)
研究者
研究点 (1)
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