Study to Compare the Type of Pressure Selection using predesigned table(LOW-PEEP/HIGH-FIO2 table )with Conventional method in Machine Assisted Breathing in children with severe acute lung injury.

Not Applicable

• Conditions: Health Condition 1: J80- Acute respiratory distress syndrome

• Registration Number: CTRI/2024/03/063498
• Lead Sponsor: Rainbow Childrens Medicare Ltd

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 1 April 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Invasively ventilated children more than 1 month and up to 18 years age with pARDS diagnosed as per PALICC-2

Exclusion Criteria

1.Children who are not intubated

2.Children who are already on High Frequency Oscillatory ventilation.

3.Children with open chest (following surgery)

4.Children with raised Intra cranial pressure

5.children with post cardiac arrest, neuromuscular disorder, congenital heart disease, mechanical ventilation of more than 1-week, uncontrolled terminal illness,

6.Previous barotrauma (pneumothorax, pneumomediastinum or subcutaneous emphysema)

7.When treating consultant refuses to participate (Due to unacceptable Vt, hemodynamic instability, radiological/ clinical evidence of lung hyperinflation)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br/ ><br>To assess the changes in oxygenation index at the end of 48 hrsTimepoint: <br/ ><br>To assess the changes in oxygenation index at the end of 48 hrs

Secondary Outcome Measures

Name	Time	Method
28-Day ventilation Free days and Mortality difference between the groups.Timepoint: 28 days;28-Day ventilation Free days and Mortality difference between the groups. <br/ ><br>•28- day ventilator free days, <br/ ><br>•28-day mortality, <br/ ><br>•90 days mortality, <br/ ><br>•Incidence of air leak, <br/ ><br>•length of PICU stay, <br/ ><br>•length of hospital stay <br/ ><br>•Organ failure free days.Timepoint: 28 days;28-Day ventilation Free days and Mortality difference between the groups. <br/ ><br>•28- day ventilator free days, <br/ ><br>•28-day mortality, <br/ ><br>•90 days mortality, <br/ ><br>•Incidence of air leak, <br/ ><br>•length of PICU stay, <br/ ><br>•length of hospital stay <br/ ><br>•Organ failure free days.Timepoint: 28 days