NCT01240161已完成不适用
Personalized Translational Platform for Biomarker Discovery in Brain Tumors
Marcelo F. Di Carli, MD, FACC2 个研究点 分布在 1 个国家目标入组 37 人开始时间: 2009年12月最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- Overall Survival
研究概览
简要总结
The central hypothesis for this proposal is that multimodal (clinical, imaging, tissue) biomarkers will better predict early brain tumor response to treatments and will be more reliable prognostic markers in patients with malignant brain tumors.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed or suspected high grade glioma ≥ 1cm in diameter on postoperative anatomic imaging (contrast MRI), prior to initiation of chemoXRT
- •Anticipated survival ≥6 months
- •Able to give informed consent
- •Capable of undergoing MRI and PET scans without the need for sedation or general anesthesia
- •Male or Female
排除标准
- •Prior radiation therapy and chemotherapy to the brain
- •Active intracranial infection or nonglial brain mass.
- •Recent large intracranial hemorrhage (<1 month)
- •Expected survival <6 months
- •Pregnant or nursing
- •Renal failure
- •Lives far from BWH and/or is unwilling/ unable to return for scheduled imaging visits.
结局指标
主要结局
Overall Survival
时间窗: 7 months
Progression free Survival
时间窗: 7 months
MRI and clinical criteria
次要结局
未报告次要终点
研究者
Marcelo F. Di Carli, MD, FACC
Chief of Nuclear Medicine/PET
Brigham and Women's Hospital
研究点 (2)
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