Effect of Chronic Arsenic Exposure on Malnutrition Among Under-five Children Attending Assiut University Children Hospital
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Assiut University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Chronic Arsenic Exposure of Under Five Children
Study Overview
Brief Summary
Early life malnutrition is associated with later life health problems, Particularly Stunting, which is a height-for-age Z score less than -2 standard deviation of World Health Organization median.Underweight is weight-for-age Z score less than -2 standard deviation of World Health Organization median. Wasting is weight -for- height Z score less than -2 standard deviation of World Health Organization median.
Detailed Description
prevalence of under-five stunting, wasting and underweight are 21% and , 8% and 6% respectively in Egyptian Demographic Health Survey 2014.
The main risk factors for growth restriction in children are maternal under nutrition during pregnancy, lack of exclusive breastfeeding, inappropriate complementary feeding and micronutrient intake and high prevalence of enteric infections. However, other environmental exposures may also play a role in growth restriction .
High concentrations of Arsenic, lead and cadmium in placenta are associated with poor fetal out come and low birth weight. Arsenic crosses the placenta causing suppression of insulin-Like Growth Factor 1.
When breastfeeding is exclusive, infants are unlikely to be exposed to Arsenic by other routes of exposure such as external foods, drinking water and foods made at home using Arsenic contaminated water.
Rational of the study. Improvement of under-five nutritional status is a global target. Although the exposure to arsenic has increased globally, it's impact on nutritional status has seldom been investigated.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 2 Years to 5 Years (Child)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •female children from 2 to 5 years
Exclusion Criteria
- •Severely ill children other than severely malnourished.
- •Children with congenital anomaly.
- •Relatives.
Outcomes
Primary Outcomes
Chronic Arsenic Exposure of Under Five Children
Time Frame: one year
Hair samples collected from participating children will be analyzed for Arsenic using Agilent graphite tube atomizer (GTA) 120
weight measurement
Time Frame: one year
weight in kilograms will be measured to all participating children
height measurement
Time Frame: one year
height in meters will be measured to all participating children
Secondary Outcomes
No secondary outcomes reported
Investigators
alyaa abdelaal mohamed abdelaal
principle investigator
Assiut University