Study to explore the use of potential biomarkers of Gcase enzyme activation in healthy subjects and patients with Parkinson's Disease with and without a mutation in the GBAgene
- Conditions
- Parkinson's DiseaseZiekte van Parkinson
- Registration Number
- NL-OMON26026
- Lead Sponsor
- CHDR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
Group 1, Inclusion criteria;
1. Signed informed consent prior to any study-mandated procedure.
Exclusion Criteria
Group 1, exclusion criteria;
1. Any recent (within 7 days) infectious disease.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. GCase activity in whole-blood<br /><br>2. GCase activity in isolated PBMCs<br /><br>3. GCase protein in PBMCs<br /><br>4. GluCer in PBMCs and plasma - Potentially other substrates / products in the same metabolic pathway<br />
- Secondary Outcome Measures
Name Time Method