NCT00154050已完成不适用
High Dose Candesartan Versus Quinapril for Restenosis Prophylaxis After Stent Angioplasty
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Restenosis/reintervention after 6 months
研究概览
简要总结
The study is designed to test the hypothesis that high dose candesartan treatment compared to quinapril is able to reduce intima hyperproliferation and the restenosis rate after stent angioplasty in peripheral occlusive artery disease.
详细描述
Patients are randomly assigned to treatment with either candesartan 32 mg/d or Quinapril 20 mg/d before the angioplasty. Walking distance, intima media thickness and crurobrachial pressure ratios are compared after 6 weeks, 3 months and 6 months. After 6 months an angiographic control is performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •male and female
- •peripheral occlusive arterial disease Stad IIb Fontaine classification
排除标准
- •patients with lesions not available for PTA
- •renal insufficiency
- •patients on calcium-antagonists
结局指标
主要结局
Restenosis/reintervention after 6 months
次要结局
- crurobrachial pressure ratios
- pain-free walking distance
研究者
研究点 (2)
Loading locations...
相似试验
已完成
4 期
Efficacy of Candesartan on Reducing Blood Pressure in Insulin-Resistant, Obese Patients With Hypertension.ObesityHypertensionNCT00775814Takeda188
已完成
3 期
Efficacy of Candesartan on Symptomatic Heart Failure in Treating Diabetic and Hypertensive Patients.Heart FailureNCT00775840Takeda22
Unknown
3 期
Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive PatientsCardiovascular DiseasesHypertensionNCT00125463The Japanese Society of Hypertension3,200
Unknown
2 期
A Phase 2 Dose Selection Trial of Candesartan Cilexetil and Amlodipine Besylate to Treat Essential HypertensionEssential HypertensionNCT02059616HK inno.N Corporation384
已完成
2 期
Comparison of Efficacy and Safety of Combination Therapy and Monotherapy of Candesartan and Amlodipine for Dose-Finding in Patients With Essential HypertensionEssential HypertensionNCT02944734Shin Poong Pharmaceutical Co. Ltd.392