Neural Mobilization for Reduction of Spasticity in Stroke

Not Applicable

Completed

• Conditions: Stroke
• Interventions: Other: Median nerve mobilization

• Registration Number: NCT05314465
• Lead Sponsor: Asir John Samuel

Brief Summary

Spasticity after stroke is common that affect upper limb strength and make activities of daily living difficult. There are many techniques but not any standardized technique for long term effect on reduction of spasticity and improving upper limb strength. This study aimed to explore and understand the effectiveness of neural mobilization on reduction of spasticity and improving upper limb strength in individuals with stroke. This is mixed method approach of embedded design, multicentric study recruited 7 individuals with stroke as no new themes or codes were emerging (data saturated). Median nerve mobilization was given 20 oscillations per minute for 3 times \& repeated 3 times with a pause of 1 minute between each sets for 5times/week for 4weeks. Outcome measures were Modified Ashworth Scale (MAS), Brunnstrom's grading of hand recovery and Hydraulic hand dynamometer(HHD) for grip and pinch strength. Pre and post outcomes data were collected at baseline and 4weeks after intervention and in depth face to face structured interviews was conducted after 4weeks of intervention to explore the effectiveness of median nerve mobilization on reduction of spasticity and the improvement of upper limb strength.

Detailed Description

Spasticity after stroke is common that affect upper limb strength and make activities of daily living difficult. There are many techniques but not any standardized technique for long term effect on reduction of spasticity and improving upper limb strength. This study aimed to explore and understand the effectiveness of neural mobilization on reduction of spasticity and improving upper limb strength in individuals with stroke. This is mixed method approach of embedded design, multicentric study recruited 7 individuals with stroke as no new themes or codes were emerging (data saturated). Median nerve mobilization was given 20 oscillations per minute for 3 times \& repeated 3 times with a pause of 1 minute between each sets for 5times/week for 4weeks. Primary outcome measure was Modified Ashworth Scale (MAS) to assess elbow and wrist flexors spasticity and secondary outcome measures were Brunnstrom's stages for hand recovery and Hydraulic hand dynamometer(HHD) to measure grip and pinch strength. Pre and post outcomes data were collected at baseline and 4weeks after intervention and in depth face to face structured interviews was conducted after 4weeks of intervention to explore the effectiveness of median nerve mobilization on reduction of spasticity and the improvement of upper limb strength.

Study Timeline

• Study Start: 2021-11-22
• Primary Completion: 2022-02-19
• Study Completion: 2022-03-15
• Study First Submitted: 2022-03-30
• Study First Submitted QC: 2022-03-30
• Study First Posted: 2022-04-06
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-16
• Last Update Posted: 2022-08-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

1. Participants with subacute and chronic stroke (1month and above) having upper limb spasticity.
2. Participants with haemorrhagic and ischemic stroke.
3. Participants who tolerate the supine position.
4. Participants who are oriented and alert.
5. Both males and females.
6. Participants older than 18 years.

Exclusion Criteria

1. Participants with a score greater than 3 on The Modified Ashworth Scale.
2. Participants with affected speech.
3. Participants with upper limb deformity.
4. Participants experiencing dizziness.
5. Any increase in the dosage of anti-spastic medications during the intervention period.
6. General health problems or pathologies that affect the nervous system like uncontrolled diabetes, hypertension and recent surgeries.
7. Recent onset of worsening neurological signs.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Median nerve mobilization	Median nerve mobilization	Experimental arm given Median nerve mobilization for 12mins 3sets for 3mins each with 1 minute interval in between for 5times a week for 4weeks

Primary Outcome Measures

Name	Time	Method
Modified Ashworth Scale (MAS)	Change from baseline and 4 weeks	For spasticity, Total 4 grades are there. Grade 0 means no increase in muscle tone and grade 4 means affected part rigid in flexion or extension. More grade means more spasticity is there.

Secondary Outcome Measures

Name	Time	Method
Brunnstrom's stages for hand recovery	Change from baseline and 4 weeks	To check recovery of hand functions. Total 7 grades are there. Increase in grade means increase in hand functions.
Hydraulic hand dynamometer	Change from baseline and 4 weeks	For grip and pinch strength

Trial Locations

Locations (3)

Healing Hands Physiotherapy & Rehabilitation; 🇮🇳 Hisar, Haryana, India

Maharishi Markandeshwar Institute of Physiotherapy & Rehabilitation; 🇮🇳 Ambala, Haryana, India

Bedi Hospital; 🇮🇳 Kaithal, Haryana, India