Efficacy of sub-mucosal injection of chymotrypsin, oral serratiopeptidase and oral corticosteroids for reduction postoperative complications following impacted lower third molars surgery: a prospective, randomized, double-blinded, controlled clinical trial
- Conditions
- 1.Adult healthy patients who were American Society of Anesthesiologists (ASA) group I and required surgical extraction of unilateral or bilateral complete impacted mandibular third molars.lower third molar surgeryoral corticosteroidschymotrypsinoral serratiopeptidase
- Registration Number
- TCTR20200828006
- Lead Sponsor
- Faculty of Dentistry, University of Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
1.Adult healthy patients who were American Society of Anesthesiologists (ASA) group I and required surgical extraction of unilateral or bilateral complete impacted mandibular third molars.
2.All subjects had to presented with the same surgical difficulty concerning similar bone impaction and had the same classification in relation to the occlusal surface of the neighboring second molar (Class B: the impacted teeth are partly buried in the bone, or the occlusal plane of the impacted tooth is between the occlusal plane and the neighboring tooth's cervical line).
1.Patient administered other drugs such as NSAIDS and steroids.
2.Patient has allergy to the drugs used in this study.
3.Pregnant patient or a patient with lactation.
4.Immunocompromized patients with diabetic or hypertension (from patient’s history).
5.Patients with irradiated maxillofacial region.
6.Mentally challenged patients and patients unable to come for follow up visits.
7. patients with acute and subacute pericoronitis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pain and facial swlling 2 days, 3 days and 5 days visual analaoque sacle
- Secondary Outcome Measures
Name Time Method mouth opening day tape methods in millimeters