Genetic Origin of Lipid Disorders
- Conditions
- Lipid Disorder
- Registration Number
- NCT00277121
- Lead Sponsor
- University of Oslo
- Brief Summary
Several lipid disorders are without known genetic origin. The scope of this project is to sequence genes superior involved in lipid and carbohydrate metabolism in patients with severe lipid disorders. The resulting mutations will be tested in suitable in vitro systems to detect their part in development of the specific disease.
- Detailed Description
See "brief summary" above.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- proven written informed consent prior to recruitment
- male or female
- 18-55 years old
- patients with severe lipid disorders
- fasting plasma cholesterol, triglyceride or glucose, blood pressure or waist circumference/BMI out of normal range
Exclusion Criteria
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What key genes or pathways in lipid and carbohydrate metabolism were sequenced in NCT00277121 for therapeutic targeting?
How do NCT00277121's genetic findings compare to standard-of-care for familial hypercholesterolemia and lipid disorders?
Which biomarkers from NCT00277121 predict response to lipid-lowering therapies in monogenic lipid disorders?
What adverse events are linked to lipid metabolism gene mutations in NCT00277121, and how are they managed?
What novel drug targets or combinations arise from NCT00277121's findings on lipid metabolism gene mutations in dysbetalipoproteinemia?
Trial Locations
- Locations (1)
Department of Nutrition, University of Oslo
🇳🇴Oslo, Norway
Department of Nutrition, University of Oslo🇳🇴Oslo, Norway