The Impact of Dry Eye Syndrome on Metrics of Low Contrast Vision Before and After Meibomian Gland Expression
- Conditions
- Meibomian Gland Dysfunction
- Interventions
- Procedure: Meibomian gland (MG) expression
- Registration Number
- NCT05713981
- Lead Sponsor
- University of the Incarnate Word
- Brief Summary
The study aims to determine the impact of Meibomian Gland Dysfunction (MGD) dry eye on low contrast black/white (luminance) and cone color sensitivity performance and improvement in these functions after in-house non-invasive Meibomian gland (MG) expression.
- Detailed Description
This study offers possible benefits from gland expression to patients and subjects in terms of clinical measurements and care associated with meibomian gland dysfunction impacting all age ranges. Prior studies show that these interventions improve dry eye symptoms with intent to improve vision, low contrast color, and B/W vision after intervention in this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Individuals over the age of 18 years
- Healthy individuals with reported symptoms of dry eye such as burning, stinging, fluctuating vision, inappropriate tearing, and feelings of grittiness particularly with prolonged near work
- Under the age of 18
- Individuals currently using prescription eye medications for dry eye / MGD / inflammation / Infections or any other treatments.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description non-invasive Meibomian gland (MG) expression Meibomian gland (MG) expression Baseline testing of visual acuity, contrast sensitivity, color vision, and Innova, Inc. cone and B/W low contrast vision will be measured. The intervention will be standard clinical expression of Meibomian superior and inferior glands (MG) using a sterile cotton tip applicator to apply gentle pressure in a rolling motion in the direction of the MGs along the upper and lower eyelid margins to allow oil secretion of the tested eye. One drop of sterile saline will be instilled following the intervention to remove debris. The subject's visual acuity, contrast sensitivity, color vision, and Innova, Inc. cone and B/W low contrast vision will be measured before and after this intervention.
- Primary Outcome Measures
Name Time Method Change in Response Time on Cone Contrast Test (CCT, Innova Systems, Inc.) This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures average response time in seconds to see red, green and blue low contrast letters.
Change in Cone Contrast Sensitivity on the Cone Contrast Test (CCT, Innova Systems, Inc.) This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures the lowest contrast (contrast sensitivity) to see red, green and blue cone specific letters.
- Secondary Outcome Measures
Name Time Method Change in Visual Acuity Test at Low Contrast (Innova Systems, Inc) This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures the smallest low contrast letters which can be seen.
Change in Response Time on Black White Contrast Sensitivity Test (Innova Systems, Inc) Response Time This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures average response time in seconds to see low contrast black/white letters
Change in Black White Contrast Sensitivity (Innova Systems, Inc) This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures the lowest contrast (contrast sensitivity) to see black/white letters.
Change in Response Time on Visual Acuity Test at Low Contrast (Innova Systems, Inc) This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures average response time in seconds to see low contrast visual acuity letters
Change in Color Naming Accuracy on Cone Contrast Color Naming test (CCNT) This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures the accuracy of naming (number correct) low contrast red, green, blue and grey letters.
Change in Sensitivity on Cone Contrast Color Naming test (CCNT) This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention. This computer test measures the lowest contrast (contrast sensitivity) to see red, green, blue and grey letters.
Trial Locations
- Locations (1)
University of the Incarnate Word Rosenberg School of Optometry
🇺🇸San Antonio, Texas, United States