Association Between Serum Leucine-rich Alpha-2 Glycoprotein Levels and Endoscopic Activity of Possible Ulcerative Colitis or Crohn's Disease Colitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 673
- 试验地点
- 1
- 主要终点
- Serum LRG measurement
研究概览
简要总结
We attempt to examine the association between serum leucine-rich alpha-2 glycoprotein (LRG) levels and endoscopic activity in patients with possible ulcerative colitis (UC) or Crohn's disease (CD) to determine whether LRG was a predicting marker for UC or CD.
详细描述
Serum samples were collected from patients, and scores for clinical and endoscopic activity of disease were obtained by reviewing the clinical records of patients. Serum sampling and colonoscopy with histology were performed within 7 days.The disease activity of UC and CD patients was evaluated by the Mayo score and Crohn disease activity index (CDAI), respectively. The Mayo endoscopy score was evaluated. UC patients whose Mayo endoscopy score was 2 or 3 were divided into the active UC group.
CD patients whose CDAI >150 were divided into the active CD group.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients whom possible UC or Crohn disease was suspected
排除标准
- •other autoimmune diseases
- •acute or chronic renal failure
- •chronic heart diseases
- •liver cirrhosis
- •acute or chronic systemic infections
- •ischemic colitis
结局指标
主要结局
Serum LRG measurement
时间窗: one year
Serum samples were collected from patients, and scores for clinical and endoscopic activity of disease were obtained by reviewing the clinical records of patients.
次要结局
未报告次要终点
研究者
Akira Horiuchi
Chief
Showa Inan General Hospital