ChiCTR-IOR-15005942尚未招募不适用
運動訓練與工作記憶訓練對減慢輕度阿氏痴呆症長者認知能力下降之隨機對比研究
Health and Medical Research Fund1 个研究点 分布在 1 个国家目标入组 376 人开始时间: 2015年2月14日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 376
- 试验地点
- 1
- 主要终点
- Global cognitive function
研究概览
简要总结
運動訓練與工作記憶訓練對減慢輕度阿氏痴呆症長者認知能力下降
研究设计
- 研究类型
- 干预性研究
- 主要目的
- 随机平行对照
- 盲法
- Single
入排标准
- 年龄范围
- 60 至 90（—）
- 性别
- All
入选标准
- •Subjects from 60 to 90 years old;
- •DSM-5 diagnosis of Major Neurocognitive Disorder due to AD (22), which would satisfy the criteria for significant cognitive decline in at least one of six areas of cognition (memory, perceptual-motor, complex attention, language, executive function and social cognition) and functional disturbance, with clinical or biological features indicative of AD;
- •CDR of 1 indicating mild dementia; and
- •Ambulatory with low risk of fall as assessed by the physiotherapist (co-A).
排除标准
- •Past history of bipolar affective disorder or psychosis;
- •Physical frailty affecting attendance to training sessions;
- •Already attending regular cognitive training;
- •History of major neurological deficit including history of stroke, or traumatic brain injury; and
- •Significant communicative impairments.
研究组 & 干预措施
Two groups
Physical exercise and Working memory training versus either physical exercise (PE) training, working memory (WM) training, combined PE-WM training, or caregiver education in six weeks intervention
结局指标
主要结局
Global cognitive function
时间窗: baseline, 6th week and 12th weeks
次要结局
- Clinical Dementia Rating (CDR)
- Working memory test(at baseline, 6th and 12th weeks)
- Memory and language tests
- changes in neuropsychiatric symptoms across
- The Disability Assessment for Dementia (DAD)
- Subjective sense of exertion
- Quality of Life –AD.
- Leisure activity participation
- Adverse events(at baseline, 6th week and 12th weeks)
研究者
研究点 (1)
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