In Vivo Evaluation of Growth and Risk of Rupture of Dilated Ascending Aorta Using 4D Cardiac Magnetic Resonance
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aortic Rupture
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Enrollment
- 41
- Locations
- 1
- Primary Endpoint
- Correlation between wall shear stress (WSS) and aorta diameter in patient with dilated ascending aorta
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Ascending aorta aneurysmal disease is common and can be complicated by dissection or rupture. There is substantial variation in individual aneurysm progression: established risk factors for an accelerated aneurysm growth rate include initial size or localization, the presence of aortic valve disease, congenital bicuspid aortic valve or connective tissue disorders.
Detailed Description
Although there is an increased lifetime risk when the aortic diameter exceeds 6 cm, predicting aneurysm progression is nearly impossible and dissection and rupture also occur at diameters under 6 cm. The assessment of aortic hemodynamics and the presence of altered flow patterns, as well as distribution and changes in wall shear stress (WSS) and the oscillatory shear index (OSI), using 4D phase contrast cardiovascular magnetic resonance (CMR) may provide further insights in how aneurysms develop and in assessing the risk of dissection. The purpose of this study was to investigate in patients with dilated ascending aorta the flow patterns and vessel wall parameters in order to correlate these hemodynamics factors with changes in aorta size.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 years.
- •Supra-coronary aortic diameter measured by CT-scan or transthoracic/trans-esophageal echocardiography between 40 and 45 mm in case of presence of aortic valve disease, bicuspid aortic valve or connective tissue disease and between 40 and 50 mm in case of absence of aortic valve disease, bicuspid aortic valve disease or connective tissue.
- •Informed consent for participation in the study
Exclusion Criteria
- •Contraindication to MRI
- •Patient's refusal to participate in the study and / or inability to express agreement or signing the informed consent.
Outcomes
Primary Outcomes
Correlation between wall shear stress (WSS) and aorta diameter in patient with dilated ascending aorta
Time Frame: From baseline to 1 year
Aorta diameter \[mm\] is assessed by 4D phase contrast cardiovascular magnetic resonance (CMR) Wall shear stress (WSS) in aorta \[Pa\] is assessed by 4D phase contrast cardiovascular magnetic resonance (CMR).
Secondary Outcomes
- Aorta parameters associated with change in aorta diameter(From baseline to 1 year)