Comparison of the effect of cysteamine cream and hydroquinone cream in the treatment of melasma
Phase 3
Recruiting
- Conditions
- Melasma.Chloasma
- Registration Number
- IRCT20140212016557N4
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 98
Inclusion Criteria
Epidermal melasma confirmed by Wood's lamp
Duration of melasma more than 6 months
Age 18 to 50 years
Exclusion Criteria
Dermal melasma
OCP consumption during or in the past 3 months before the study
Consumption of oral or topical corticosteroids on the site of melasma during the study
Intolerance to hydroquinone or cysteamine as severe irritation
Other pigmentary disorders
Pregnancy
Lactation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Melanin index. Timepoint: before intervention and 2 and 4 months after intervention. Method of measurement: SkinColorCatch instrument.
- Secondary Outcome Measures
Name Time Method Modified Melasma Area and Severity Scale score. Timepoint: before intervention and 2 and 4 months after intervention. Method of measurement: modified Melasma Area and Severity Scale score formula.;Lee's investigator global assessment score. Timepoint: 2 and 4 months after intervention. Method of measurement: 5-point Likert scale for Lee's investigator global assessment score.;Lee's patient global assessment score. Timepoint: 2 and 4 months after intervention. Method of measurement: 5-point Likert scale for Lee's patient global assessment score.