Protective Ventilation With Carbon Dioxide (CO2) -Removal Technique in Patients With Adult Respiratory Distress Syndrome (ARDS)
- Conditions
- Adult Respiratory Distress Syndrome
- Registration Number
- NCT00465309
- Lead Sponsor
- University of Turin, Italy
- Brief Summary
30% of ARDS patients ventilated according to NIH protocol presents morphological (CT) and functional (Stress Index\>1) conditions of hyperinflation even with Plateau pressure (Pplat) \< 30 cmH2O; values of Pplat lower than 26 cmH2O were associated with more a condition of more protective ventilation.
In patients at risk of hyperinflation, use of alternative techniques such as CO2-removal my allow the reduction of Tidal Volume (Vt) and Pplat.
- Detailed Description
Aim of the study was to verify the efficacy of CO2-removal technique in reducing Vt and consequently Pplat to obtain a Stress Index value equal to 1.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- ARDS patients with Pplat >= 26 during NIH protective ventilation protocol
- Age < 18 years
- Brain injury and patients with intracranial pressure > 20 mmHg
- Pregnancy
- Immunodepressed patients
- Patients already enrolled in other trials
- Renal replacement therapy
- BMI > 40
- Contraindication anticoagulation treatment
- Morphological abnormalities of femoral veins
- NYHA III-IV
- Burns BSA>30%
- Hepatic failure (grade C Child)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method pulmonary inflammatory mediator reduction within the first 72 hours after enrollment
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
University of Turin, Department of Anesthesia and Intensive Care Medicine
🇮🇹Turin, Italy
University of Turin, Department of Anesthesia and Intensive Care Medicine,S. G. Battista Hospital
🇮🇹Turin, Italy