An evaluation of prednisolone to treat viral associated wheeze in pre-school aged children.
- Conditions
- Wheeze.Viral upper respiratory tract infection.Respiratory - AsthmaInfection - Other infectious diseases
- Registration Number
- ACTRN12612000394842
- Lead Sponsor
- Dr Steven Foster - ED Fellow
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 700
1. Clinical diagnosis of wheeze.
2. Presence of symptoms or signs of an intercurrent or recent (within 72hrs) viral upper respiratory tract infection.
1. Presenting oxygen saturation (SpO2) less than 92% in room air.
2. Features of critical wheeze - (silent chest on auscultation and/or exhaustion with or without cyanosis)
3. Clinical evidence of shock or bacterial sepsis.
4. Active varicella infection.
5. High clinical suspicion of alternative diagnosis for wheeze (for example - inhaled foreign body).
6. Previous PICU admission with wheeze / asthma.
7. Premature birth - defined as <34 weeks gestation.
8. Known cardiac / other respiratory disease.
9. Recieving immunosuppresant therapy or known to have immunodeficiency.
10. Upper respiratory tract structural abnormality.
11. Oral corticosteroid therapy within the last 14 days.
12. Previously recruited to this study.
13. Known allergy to Prednisolone.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ength of stay (LOS) within the Emergency Department (ED) from time study drug administered until the patient is deemed fit for discharge.[From time of study drug adminstration until discharge-ready time and actual discharge time.];Length of stay (LOS) within the hospital from time study drug administered until the patient is deemed fit for discharge.[From time of study drug administration until discharge-ready time and actual discharge time]
- Secondary Outcome Measures
Name Time Method