A prospective, randomized, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of VITEX extract in subjects suffering with Post Menopausal Syndrome.

Postmenopausal Syndrome (PMS) refers to a collection of symptoms occurring after the cessation of menstruation, affecting women’s physical, emotional, and mental well-being. With aging populations globally, effective management of PMS has become a public health priority.Menopause symptoms severely reduce the quality of life of women worldwide, with up to 80% of women experiencing symptoms. It is estimated that by 2030, the groups of post-menopausal women will reach 1.2 billion globally (Gold et al. 2006). During menopause, women undergo biological, social, and psychological changes and are sensitive to stressors, especially anxiety and depression. Decreased estrogen in postmenopausal women causes mood swings, especially depression and anxiety. Menopausal symptoms have remarkable negative effects on women’s quality of life, justifying the need to assess various therapeutic options.

Vitex is a genus belonging to the sage family, Lamiaceae, and comprises around 250 species. Commonly referred to as the chaste tree or chastetree, the term often specifically denotes Agnus castus but is also applied to other species. Native to regions of middle Asia and the Mediterranean, Vitex has a long history of use in treating various menstrual issues. Historically, it was believed to reduce sexual desire, which is why it is called the "chaste tree," with “agnus” meaning "chaste" in Greek and “castus” carrying the same meaning in Latin. The chaste tree (Vitex agnus-castus) contains a diverse range of chemical components, including Flavonoids, Glycosides, Organic acids, Alkaloids, Essential oils, Diterpenoids and Sterols. Although its active ingredient has not been identified, the herb’s bioactive constituents, particularly flavonoids and diterpenes, contribute to its therapeutic properties. Derived from the fruit of Vitex agnus castus (Chasteberry). Extracts of chaste tree are prepared from the leaves, tender stems, flowers, and seeds and provided as syrup, elixir, powder, or a component of a multi ingredient dietary supplement. Also available in various forms: capsules, tablets, supplements. Traditionally used for hormonal balance, menstrual issues, and menopausal symptoms May help with PMS symptoms, Menstrual irregularities, Fertility issues and Menopausal symptoms (hot flashes, mood swings).